Antiulcer activity of Paliperidone was studied in rats in which gastric ulcers were induced by oral administration of ethanol or by pyloric ligation. The antiemetic activity was studied by chick emesis model. The antiulcer and antiemetic activities were assessed by determining and comparing the ulcer index in rats and number of retches in chicks in the test drug group with that of the control group. Ranitidine, Sucralfate, Domperidone were used as a reference drug. The ulcer index in the Paliperidone treated animals was found to be significantly less in all the models compared to vehicle control animals. Similarly the number of retches in the Paliperidone treated animals was found to be significantly less in chick emesis model compared to vehicle control animals This antiulcer property was more prominent in animals in whom ulcers were induced by ethanol and pyloric ligation. The anti-ulcer and antiemetic activities of Paliperidone were however, less than that of standard. Our results suggest that Paliperidone possesses significant antiulcer property as well as antiemetic property.
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